Mikelis Laboratory – Biomedical Sciences

1. Encapsulation of Microalgae Tisochrysis lutea Extract in Nanostructured Lipid Carriers (NLCs) and Evaluation of Their Sunscreen, Wound Healing, and Skin Hydration Properties.

Chatzopoulou N, Chaikali C, Mourkogianni E, Mikelis CM, Andriopoulos V, Kornaros M, Avgoustakis K, Lamari FN, Hatziantoniou S.Mar Drugs. 2024 Oct 30;22(11):487. doi: 10.3390/md22110487.PMID: 39590769 Free PMC article.

2. The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology.

Plevriti A, Lamprou M, Mourkogianni E, Skoulas N, Giannakopoulou M, Sajib MS, Wang Z, Mattheolabakis G, Chatzigeorgiou A, Marazioti A, Mikelis CM.Cells. 2024 Oct 11;13(20):1679. doi: 10.3390/cells13201679.PMID: 39451197 Free PMC article. Review.

3. Association of Circulating Robo4 with Obesity, Hypertension and Atherosclerotic Plaque Burden.

Vlachogiannis NI, Legaki AI, Kassi E, Mikelis CM, Tentolouris N, Sfikakis PP, Protogerou AD, Chatzigeorgiou A.Thromb Haemost. 2024 Nov 11. doi: 10.1055/a-2437-6308. Online ahead of print.PMID: 39401520 No abstract available.

4. Tumor-induced endothelial RhoA activation mediates tumor cell transendothelial migration and metastasis.

Sajib MS, Zahra FT, Lamprou M, Akwii RG, Park JH, Osorio M, Tullar P, Doci CL, Zhang C, Huveneers S, Van Buul JD, Wang MH, Markiewski MM, Srivastava SK, Zheng Y, Gutkind JS, Hu J, Bickel U, Maeda DY, Zebala JA, Lionakis MS, Trasti S, Mikelis CM.bioRxiv [Preprint]. 2024 Sep 24:2024.09.22.614304. doi: 10.1101/2024.09.22.614304.PMID: 39372784 Free PMC article. Preprint.

5. Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery.

Haque MA, Shrestha A, Mikelis CM, Mattheolabakis G.Int J Pharm X. 2024 Sep 10;8:100283. doi: 10.1016/j.ijpx.2024.100283. eCollection 2024 Dec.PMID: 39309631 Free PMC article. Review.

6. Stable Dual miR-143 and miR-506 Upregulation Inhibits Proliferation and Cell Cycle Progression.

Shrestha A, Lahooti B, Hossian AKMN, Madadi M, Mikelis CM, Mattheolabakis G.Int J Mol Sci. 2024 Apr 17;25(8):4432. doi: 10.3390/ijms25084432.PMID: 38674017 Free PMC article.

7. Development and Evaluation of Biodegradable Core-Shell Microfibrous and Nanofibrous Scaffolds for Tissue Engineering Applications.

Mitropoulou A, Markatos DN, Dimopoulos A, Marazioti A, Mikelis CM, Mavrilas D.J Mater Sci Mater Med. 2024 Jan 29;35(1):10. doi: 10.1007/s10856-024-06777-z.PMID: 38285092 Free PMC article.

8. Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines.

Bandy R, Shahi S, Quagraine N, Shahbazi Nia S, Howlader MSI, Srivenugopal K, Stephan C, Das H, Mikelis CM, German NA.ACS Pharmacol Transl Sci. 2023 Dec 15;7(1):120-136. doi: 10.1021/acsptsci.3c00193. eCollection 2024 Jan 12.PMID: 38230276 Free PMC article.

9. Murine Dermal Lymphatic Endothelial Cell Isolation.

Akwii RG, Lamprou M, Georgomanoli M, Plevriti A, Marazioti A, Mouzaki A, Mattheolabakis G, Mikelis CM.J Vis Exp. 2023 Jul 21;(197). doi: 10.3791/65393.PMID: 37590510

10. Targeting endothelial permeability in the EPR effect.

Lahooti B, Akwii RG, Zahra FT, Sajib MS, Lamprou M, Alobaida A, Lionakis MS, Mattheolabakis G, Mikelis CM.J Control Release. 2023 Sep;361:212-235. doi: 10.1016/j.jconrel.2023.07.039. Epub 2023 Aug 8.PMID: 37517543 Review.

Kastana P, Ntenekou D, Mourkogianni E, Enake MK, Xanthopoulos A, Choleva E, Marazioti A, Nikou S, Akwii RG, Papadaki E, Gramage E, Herradón G, Stathopoulos GT, Mikelis CM, Papadimitriou E.Int J Cancer. 2023 Sep 1;153(5):1051-1066. doi: 10.1002/ijc.34564. Epub 2023 Jun 1.PMID: 37260355 Free PMC article.

12. Endothelial-Specific Targeting of RhoA Signaling via CD31 Antibody-Conjugated Nanoparticles.

Lahooti B, Akwii RG, Patel D, ShahbaziNia S, Lamprou M, Madadi M, Abbruscato TJ, Astrinidis A, Bickel U, Al-Ahmad A, German NA, Mattheolabakis G, Mikelis CM.J Pharmacol Exp Ther. 2023 Apr;385(1):35-49. doi: 10.1124/jpet.122.001384. Epub 2023 Feb 6.PMID: 36746610 Free PMC article.

13. Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery.

Shrestha A, Lahooti B, Mikelis CM, Mattheolabakis G.Pharmaceutics. 2022 Nov 26;14(12):2613. doi: 10.3390/pharmaceutics14122613.PMID: 36559106 Free PMC article.

Drummond RA, Desai JV, Hsu AP, Oikonomou V, Vinh DC, Acklin JA, Abers MS, Walkiewicz MA, Anzick SL, Swamydas M, Vautier S, Natarajan M, Oler AJ, Yamanaka D, Mayer-Barber KD, Iwakura Y, Bianchi D, Driscoll B, Hauck K, Kline A, Viall NS, Zerbe CS, Ferré EM, Schmitt MM, DiMaggio T, Pittaluga S, Butman JA, Zelazny AM, Shea YR, Arias CA, Ashbaugh C, Mahmood M, Temesgen Z, Theofiles AG, Nigo M, Moudgal V, Bloch KC, Kelly SG, Whitworth MS, Rao G, Whitener CJ, Mafi N, Gea-Banacloche J, Kenyon LC, Miller WR, Boggian K, Gilbert A, Sincock M, Freeman AF, Bennett JE, Hasbun R, Mikelis CM, Kwon-Chung KJ, Belkaid Y, Brown GD, Lim JK, Kuhns DB, Holland SM, Lionakis MS.J Clin Invest. 2022 Nov 15;132(22):e159348. doi: 10.1172/JCI159348.PMID: 36377664 Free PMC article.

Ashraf-Uz-Zaman M, Ji G, Tidwell D, Yin L, Thakolwiboon S, Pan J, Junell R, Griffin Z, Shahi S, Barthels D, Sajib MS, Trippier PC, Mikelis CM, Das H, Avila M, Neugebauer V, German NA.ACS Chem Neurosci. 2022 Nov 2;13(21):3138. doi: 10.1021/acschemneuro.2c00459. Epub 2022 Oct 20.PMID: 36264675 No abstract available.

Pervaiz I, Zahra FT, Mikelis CM, Al-Ahmad AJ.J Neurochem. 2022 Sep;162(6):483-500. doi: 10.1111/jnc.15684. Epub 2022 Aug 19.PMID: 35943296 Free article.

Huwaimel BI, Jonnalagadda S, Jonnalagadda S, Zahra FT, Nocentini A, Supuran CT, Mikelis CM, Trippier PC.Bioorg Med Chem. 2022 Aug 1;67:116805. doi: 10.1016/j.bmc.2022.116805. Epub 2022 May 15.PMID: 35635929 Free PMC article.

Noorani B, Chowdhury EA, Alqahtani F, Sajib MS, Ahn Y, Nozohouri E, Patel D, Mikelis C, Mehvar R, Bickel U.Pharm Res. 2022 Feb;39(2):251-261. doi: 10.1007/s11095-022-03175-4. Epub 2022 Feb 10.PMID: 35146590 Free PMC article.

Akwii RG, Sajib MS, Zahra FT, Tullar P, Zabet-Moghaddam M, Zheng Y, Silvio Gutkind J, Doci CL, Mikelis CM.Angiogenesis. 2022 Aug;25(3):373-396. doi: 10.1007/s10456-022-09831-y. Epub 2022 Feb 1.PMID: 35103877

Ashraf-Uz-Zaman M, Ji G, Tidwell D, Yin L, Thakolwiboon S, Pan J, Junell R, Griffin Z, Shahi S, Barthels D, Sajib MS, Trippier PC, Mikelis CM, Das H, Avila M, Neugebauer V, German NA.ACS Chem Neurosci. 2022 Jan 19;13(2):217-228. doi: 10.1021/acschemneuro.1c00647. Epub 2022 Jan 3.PMID: 34978174 Free PMC article.

Lahooti B, Poudel S, Mikelis CM, Mattheolabakis G.Front Oncol. 2021 Dec 9;11:705634. doi: 10.3389/fonc.2021.705634. eCollection 2021.PMID: 34956857 Free PMC article. Review.

Katraki-Pavlou S, Kastana P, Bousis D, Ntenekou D, Varela A, Davos CH, Nikou S, Papadaki E, Tsigkas G, Athanasiadis E, Herradon G, Mikelis CM, Beis D, Papadimitriou E.Am J Physiol Heart Circ Physiol. 2022 Jan 1;322(1):H8-H24. doi: 10.1152/ajpheart.00400.2021. Epub 2021 Nov 12.PMID: 34767486 Free PMC article.

Akwii RG, Mikelis CM.Drugs. 2021 Oct;81(15):1731-1749. doi: 10.1007/s40265-021-01605-y. Epub 2021 Sep 29.PMID: 34586603 Free PMC article. Review.

Zahra FT, Sajib MS, Mikelis CM.Cancers (Basel). 2021 Mar 20;13(6):1422. doi: 10.3390/cancers13061422.PMID: 33804681 Free PMC article. Review.

25. Advanced bioinformatic analysis and pathway prediction of NSCLC cells upon cisplatin resistance.

Hossian AKMN, Zahra FT, Poudel S, Abshire CF, Polk P, Garai J, Zabaleta J, Mikelis CM, Mattheolabakis G.Sci Rep. 2021 Mar 22;11(1):6520. doi: 10.1038/s41598-021-85930-y.PMID: 33753779 Free PMC article.

Al Shoyaib A, Alamri FF, Biggers A, Karamyan ST, Arumugam TV, Ahsan F, Mikelis CM, Al-Hilal TA, Karamyan VT.Neuroscience. 2021 May 1;461:57-71. doi: 10.1016/j.neuroscience.2021.02.023. Epub 2021 Mar 2.PMID: 33667592 Free PMC article.

Ziogas A, Sajib MS, Lim JH, Alves TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D.FASEB J. 2021 Mar;35(3):e21425. doi: 10.1096/fj.202001634R.PMID: 33566443 Free PMC article.

Kinarivala N, Morsy A, Patel R, Carmona AV, Sajib MS, Raut S, Mikelis CM, Al-Ahmad A, Trippier PC.ACS Pharmacol Transl Sci. 2020 Sep 1;3(5):931-947. doi: 10.1021/acsptsci.0c00077. eCollection 2020 Oct 9.PMID: 33073192 Free PMC article.

Ashraf-Uz-Zaman M, Shahi S, Akwii R, Sajib MS, Farshbaf MJ, Kallem RR, Putnam W, Wang W, Zhang R, Alvina K, Trippier PC, Mikelis CM, German NA.Eur J Med Chem. 2021 Jan 1;209:112866. doi: 10.1016/j.ejmech.2020.112866. Epub 2020 Sep 24.PMID: 33039722 Free PMC article.

30. Identification of Rho GEF and RhoA Activation by Pull-Down Assays.

Sajib MS, Zahra FT, Akwii RG, Mikelis CM.Methods Mol Biol. 2021;2193:97-109. doi: 10.1007/978-1-0716-0845-6_10.PMID: 32808262

31. In Vivo Ear Sponge Lymphangiogenesis Assay.

Akwii RG, Sajib MS, Zahra FT, Madala HR, Srivenugopal KS, Mikelis CM.Methods Mol Biol. 2021;2193:85-96. doi: 10.1007/978-1-0716-0845-6_9.PMID: 32808261

32. Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay.

Zemkewicz JL, Akwii RG, Mikelis CM, Doçi CL.Methods Mol Biol. 2021;2193:1-11. doi: 10.1007/978-1-0716-0845-6_1.PMID: 32808253

33. Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on α_νβ₃ integrin expression.

Lamprou M, Kastana P, Kofina F, Tzoupis Η, Barmpoutsi S, Sajib MS, Koutsioumpa M, Poimenidi E, Zompra AA, Tassopoulos D, Choleva E, Tselios T, Mikelis CM, Papadimitriou E.Angiogenesis. 2020 Nov;23(4):621-636. doi: 10.1007/s10456-020-09733-x. Epub 2020 Jul 17.PMID: 32681389

Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe JD, Mikelis CM, Hla T, Srinivasan RS.JCI Insight. 2020 Jul 23;5(14):e137652. doi: 10.1172/jci.insight.137652.PMID: 32544090 Free PMC article.

35. Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview.

Ashraf-Uz-Zaman M, Bhalerao A, Mikelis CM, Cucullo L, German NA.Cancers (Basel). 2020 May 17;12(5):1265. doi: 10.3390/cancers12051265.PMID: 32429547 Free PMC article. Review.

Stratman AN, Farrelly OM, Mikelis CM, Miller MF, Wang Z, Pham VN, Davis AE, Burns MC, Pezoa SA, Castranova D, Yano JJ, Kilts TM, Davis GE, Gutkind JS, Weinstein BM.Nat Commun. 2020 Mar 5;11(1):1204. doi: 10.1038/s41467-020-14956-z.PMID: 32139674 Free PMC article.

37. Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis.

Srivastava S, Zahra FT, Gupta N, Tullar PE, Srivastava SK, Mikelis CM.Int J Mol Sci. 2020 Jan 23;21(3):755. doi: 10.3390/ijms21030755.PMID: 31979394 Free PMC article.

Mattheolabakis G, Mikelis CM.Front Oncol. 2019 Nov 12;9:1227. doi: 10.3389/fonc.2019.01227. eCollection 2019.PMID: 31799190 Free PMC article. Review.

Zahra FT, Sajib MS, Ichiyama Y, Akwii RG, Tullar PE, Cobos C, Minchew SA, Doçi CL, Zheng Y, Kubota Y, Gutkind JS, Mikelis CM.Sci Rep. 2019 Aug 12;9(1):11666. doi: 10.1038/s41598-019-48053-z.PMID: 31406143 Free PMC article.

Main KA, Mikelis CM, Doçi CL.Methods Mol Biol. 2020;2109:147-154. doi: 10.1007/7651_2019_235.PMID: 31123996

Akwii RG, Sajib MS, Zahra FT, Mikelis CM.Cells. 2019 May 17;8(5):471. doi: 10.3390/cells8050471.PMID: 31108880 Free PMC article. Review.

42. Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis.

Hossian AKMN, Muthumula CMR, Sajib MS, Tullar PE, Stelly AM, Briski KP, Mikelis CM, Matthaiolampakis G.J Vis Exp. 2019 Mar 30;(145). doi: 10.3791/59460.PMID: 30985742

Kastana P, Zahra FT, Ntenekou D, Katraki-Pavlou S, Beis D, Lionakis MS, Mikelis CM, Papadimitriou E.Methods Mol Biol. 2019;1952:219-232. doi: 10.1007/978-1-4939-9133-4_18.PMID: 30825178

Zahra FT, Choleva E, Sajib MS, Papadimitriou E, Mikelis CM.Methods Mol Biol. 2019;1952:211-218. doi: 10.1007/978-1-4939-9133-4_17.PMID: 30825177

45. DNA Repair Response Adaptors: Novel Targets for Vasoproliferative Retinopathy?

Sajib MS, Mikelis CM.Thromb Haemost. 2019 Mar;119(3):358. doi: 10.1055/s-0038-1677022. Epub 2019 Jan 8.PMID: 30620993

Ashraf-Uz-Zaman M, Sajib MS, Cucullo L, Mikelis CM, German NA.Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3652-3657. doi: 10.1016/j.bmcl.2018.10.036. Epub 2018 Oct 24.PMID: 30389290 Free PMC article.

47. Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro.

Hossian AKMN, Sajib MS, Tullar PE, Mikelis CM, Mattheolabakis G.Sci Rep. 2018 Jul 12;8(1):10495. doi: 10.1038/s41598-018-28872-2.PMID: 30002440 Free PMC article.

Punganuru SR, Madala HR, Mikelis CM, Dixit A, Arutla V, Srivenugopal KS.Oncotarget. 2018 May 25;9(40):26109-26129. doi: 10.18632/oncotarget.25450. eCollection 2018 May 25.PMID: 29899846 Free PMC article.

49. GM-CSF therapy in human caspase recruitment domain-containing protein 9 deficiency.

Drummond RA, Zahra FT, Natarajan M, Swamydas M, Hsu AP, Wheat LJ, Gavino C, Vinh DC, Holland SM, Mikelis CM, Lionakis MS.J Allergy Clin Immunol. 2018 Oct;142(4):1334-1338.e5. doi: 10.1016/j.jaci.2018.05.025. Epub 2018 Jun 8.PMID: 29890237 No abstract available.

50. The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

Collar AL, Swamydas M, O’Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS.JCI Insight. 2018 Feb 8;3(3):e95417. doi: 10.1172/jci.insight.95417. eCollection 2018 Feb 8.PMID: 29415879 Free PMC article.

51. Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions.

Sajib S, Zahra FT, Lionakis MS, German NA, Mikelis CM.Angiogenesis. 2018 Feb;21(1):1-14. doi: 10.1007/s10456-017-9583-4. Epub 2017 Nov 6.PMID: 29110215 Review.

Ranjan A, German N, Mikelis C, Srivenugopal K, Srivastava SK.Tumour Biol. 2017 Jun;39(6):1010428317705517. doi: 10.1177/1010428317705517.PMID: 28618969 Free article.

Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS.PLoS One. 2017 Mar 16;12(3):e0173692. doi: 10.1371/journal.pone.0173692. eCollection 2017.PMID: 28301547 Free PMC article.

Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, Drummond RA, Rongkavilit C, Hoffman K, Henderson C, Clark L, Mezger M, Swamydas M, Engeholm M, Schüle R, Neumayer B, Ebel F, Mikelis CM, Pittaluga S, Prasad VK, Singh A, Milner JD, Williams KW, Lim JK, Kwon-Chung KJ, Holland SM, Hartl D, Kuijpers TW, Lionakis MS.JCI Insight. 2016 Oct 20;1(17):e89890. doi: 10.1172/jci.insight.89890.PMID: 27777981 Free PMC article.

55. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.

Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS.PLoS Pathog. 2015 Dec 17;11(12):e1005293. doi: 10.1371/journal.ppat.1005293. eCollection 2015 Dec.PMID: 26679537 Free PMC article.

56. Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

O’Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS.Oncogene. 2016 Jul 21;35(29):3771-80. doi: 10.1038/onc.2015.442. Epub 2015 Nov 30.PMID: 26616858 Free PMC article.

57. Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties.

Punganuru SR, Madala HR, Venugopal SN, Samala R, Mikelis C, Srivenugopal KS.Eur J Med Chem. 2016 Jan 1;107:233-44. doi: 10.1016/j.ejmech.2015.10.052. Epub 2015 Nov 2.PMID: 26599530

Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS.Cancer Res. 2015 Jul 15;75(14):2937-48. doi: 10.1158/0008-5472.CAN-14-3121. Epub 2015 May 7.PMID: 25952650 Free PMC article.

Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS.Nat Commun. 2015 Apr 10;6:6725. doi: 10.1038/ncomms7725.PMID: 25857352 Free PMC article.

Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS.FASEB J. 2015 Mar;29(3):1056-68. doi: 10.1096/fj.14-260083. Epub 2014 Dec 2.PMID: 25466898 Free PMC article.

61. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC.Oncotarget. 2014 Oct 30;5(20):9626-40. doi: 10.18632/oncotarget.2437.PMID: 25275299 Free PMC article.

62. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.

Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, Wan W, Lee CC, Lim JK, Rivollier A, Yang JC, Laird GM, Wheeler RT, Alexander BD, Perfect JR, Gao JL, Kullberg BJ, Netea MG, Murphy PM.J Clin Invest. 2013 Dec;123(12):5035-51. doi: 10.1172/JCI71307. Epub 2013 Nov 1.PMID: 24177428 Free PMC article.

63. TRAIL induces apoptosis in oral squamous carcinoma cells–a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5.

Chen JJ, Mikelis CM, Zhang Y, Gutkind JS, Zhang B.Oncotarget. 2013 Feb;4(2):206-17. doi: 10.18632/oncotarget.813.PMID: 23470485 Free PMC article.

Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS.J Biol Chem. 2013 Apr 26;288(17):12232-43. doi: 10.1074/jbc.M112.428599. Epub 2013 Mar 6.PMID: 23467409 Free PMC article.

65. Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis.

Kaspiris A, Mikelis C, Heroult M, Khaldi L, Grivas TB, Kouvaras I, Dangas S, Vasiliadis E, Lioté F, Courty J, Papadimitriou E.Joint Bone Spine. 2013 Jul;80(4):407-13. doi: 10.1016/j.jbspin.2012.10.024. Epub 2013 Jan 18.PMID: 23333521

66. Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.

Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis SS, Hellman U, Iliopoulos D, Papadimitriou E.J Biol Chem. 2013 Jan 4;288(1):343-54. doi: 10.1074/jbc.M112.387076. Epub 2012 Nov 16.PMID: 23161541 Free PMC article.

67. CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

Pan W, Pham VN, Stratman AN, Castranova D, Kamei M, Kidd KR, Lo BD, Shaw KM, Torres-Vazquez J, Mikelis CM, Gutkind JS, Davis GE, Weinstein BM.Blood. 2012 Jul 12;120(2):489-98. doi: 10.1182/blood-2012-02-408328. Epub 2012 May 30.PMID: 22649102 Free PMC article.

Koutsioumpa M, Drosou G, Mikelis C, Theochari K, Vourtsis D, Katsoris P, Giannopoulou E, Courty J, Petrou C, Magafa V, Cordopatis P, Papadimitriou E.Vasc Cell. 2012 Mar 16;4:4. doi: 10.1186/2045-824X-4-4.PMID: 22423616 Free PMC article.

Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Singh B, Weigert R, Molinolo AA, Gutkind JS.Cancer Res. 2011 Nov 15;71(22):7103-12. doi: 10.1158/0008-5472.CAN-10-3192. Epub 2011 Oct 5.PMID: 21975930 Free PMC article.

70. A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro.

Mikelis C, Lamprou M, Koutsioumpa M, Koutsioubas AG, Spyranti Z, Zompra AA, Spiliopoulos N, Vradis AA, Katsoris P, Spyroulias GA, Cordopatis P, Courty J, Papadimitriou E.J Cell Biochem. 2011 Jun;112(6):1532-43. doi: 10.1002/jcb.23066.PMID: 21344482

71. Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.

Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG.Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):151-9. doi: 10.1161/ATVBAHA.110.215871. Epub 2010 Oct 14.PMID: 20947821

Papadimitriou E, Mikelis C, Lampropoulou E, Koutsioumpa M, Theochari K, Tsirmoula S, Theodoropoulou C, Lamprou M, Sfaelou E, Vourtsis D, Boudouris P.Eur Cytokine Netw. 2009 Dec;20(4):180-90. doi: 10.1684/ecn.2009.0172.PMID: 20167557 Free article. Review.

Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E.FASEB J. 2009 May;23(5):1459-69. doi: 10.1096/fj.08-117564. Epub 2009 Jan 13.PMID: 19141530

Koutsioumpa M, Hatziapostolou M, Mikelis C, Koolwijk P, Papadimitriou E.Eur J Pharmacol. 2009 Jan 14;602(2-3):245-9. doi: 10.1016/j.ejphar.2008.11.046. Epub 2008 Dec 3.PMID: 19059395

75. Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up-regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase beta/zeta.

Polytarchou C, Hatziapostolou M, Poimenidi E, Mikelis C, Papadopoulou A, Parthymou A, Papadimitriou E.Int J Cancer. 2009 Apr 15;124(8):1785-93. doi: 10.1002/ijc.24084.PMID: 19058221

Mikelis C, Papadimitriou E.Connect Tissue Res. 2008;49(3):149-52. doi: 10.1080/03008200802148652.PMID: 18661331 Review.

Mikelis C, Koutsioumpa M, Papadimitriou E.Recent Pat Anticancer Drug Discov. 2007 Jun;2(2):175-86. doi: 10.2174/157489207780832405.PMID: 18221061 Review.

78. Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells.

Parthymou A, Lampropoulou E, Mikelis C, Drosou G, Papadimitriou E.Eur J Cell Biol. 2008 Jan;87(1):17-29. doi: 10.1016/j.ejcb.2007.07.007. Epub 2007 Sep 18.PMID: 17881084

79. Effect of heparin affin regulatory peptide on the expression of vascular endothelial growth factor receptors in endothelial cells.

Kokolakis G, Mikelis C, Papadimitriou E, Courty J, Karetsou E, Katsoris P.In Vivo. 2006 Sep-Oct;20(5):629-35.PMID: 17091770 Free article.

80. Heparin affin regulatory peptide: a new target for tumour therapy?

Papadimitriou E, Polykratis A, Hatziapostolou M, Parthymou A, Polytarchou C, Mikelis C.Curr Cancer Drug Targets. 2004 Sep;4(6):471-82. doi: 10.2174/1568009043332835.PMID: 15379633 Review.

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About Us

ANGIOGENESIS

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RESEARCH.

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Constantinos Mikelis

Margarita Lamprou

Andriana Plevriti

Maria Giannakopoulou

Margarita Kondyli

Amaryllis Fronimou

Georgios Sivvas

Md Sanaullah Sajib

Fatema Tuz Zahra

RACHEAL AKWII

Behnaz Lahooti

Spyros Artemis

Stamatis Tsantos

Sofia Lemonia Gioni

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